
Pixantrone dimaleate
CAS No. 144675-97-8
Pixantrone dimaleate ( BBR 2778 )
产品货号. M11902 CAS No. 144675-97-8
Pixantrone dimaleate (BBR 2778 dimaleate) 是一种实验性抗肿瘤化合物。
纯度: >98% (HPLC)






规格 | 价格/人民币 | 库存 | 数量 |
5MG | ¥381 | 有现货 |
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10MG | ¥583 | 有现货 |
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25MG | ¥1077 | 有现货 |
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50MG | ¥1847 | 有现货 |
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100MG | ¥2811 | 有现货 |
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500MG | ¥6683 | 有现货 |
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1G | 获取报价 | 有现货 |
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生物学信息
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产品名称Pixantrone dimaleate
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述Pixantrone dimaleate (BBR 2778 dimaleate) 是一种实验性抗肿瘤化合物。
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产品描述Pixantrone dimaleate (BBR 2778 dimaleate) is an experimental antineoplastic drug.(In Vitro):Pixantrone (0-10 μM, 72 h) dimaleate induces cell death in multiple cancer cell lines independent of cell cycle perturbation, with IC50s of 37.3 nM, 126 nM and 136 nM for T47D, MCF-10A and OVCAR5 cells, respectively.Pixantrone (25-500 nM, 2 4 h) dimaleate induces DNA damage at high concentration of 500 nM and induces severe chromosomal aberrations and mitotic catastrophe in PANC1 cells.Pixantrone (100 nM, 24 h) dimaleate may disrupt chromosome segregation because of generating merotelic kinetochore attachments that cause chromosome non-disjunction.Pixantrone (0-100 μM, 72 h) dimaleate potently inhibits growth of human leukemia K562 cells, etoposide-resistant K/VP.5 cells, MDCK and ABCB1-transfected MDCK/MDR cells with IC50s of 0.10 μM, 0.56 μM, 0.058 μM and 4.5 μM, respectively.Pixantrone (0.01-0.2 μM) dimaleate leads to a concentration-dependent formation of linear DNA through acting on topoisomerase Iiα and produces semiquinone free radicals in an enzymatic reducing system, although not in a cellular system, most likely due to low cellular uptake.Pixantrone (0.01-10 μM) dimaleate shows potent inhibitory activities against rat 97-116 peptide-specific T cell proliferation.(In Vivo):Pixantrone (i.v., 27 mg/kg, every 7 days, three times) dimaleate does not worsen pre-existing moderate degenerative cardiomyopathy, causes minimal cardiotoxic in mice following repeated treatment cycles and results in less mortality than mitoxantrone in doxorubicin-pretreated mice.Pixantrone (i.v., 16.25 mg/kg, every week, three times) dimaleate modulates Lymph node cells (LNC) responses, affacts T cell subpopulations in TAChR-immunized Lewis rats and also shows preventive and therapeutic effect in experimental autoimmune myasthenia gravis (EAMG) rats.
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体外实验——
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体内实验——
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同义词BBR 2778
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通路Others
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靶点Other Targets
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受体Others
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研究领域Cancer
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适应症——
化学信息
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CAS Number144675-97-8
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分子量557.21
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分子式C25H27N5O10
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纯度>98% (HPLC)
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溶解度DMSO: 10 mM
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SMILESC1=CC(=C2C(=O)C3=C(C(=O)C2=C1NCCN)C=CN=C3)NCCN.C(=C\C(=O)O)\C(=O)O.C(=C\C(=O)O)\C(=O)O
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Cavalletti E., et al. Invest New Drugs, 2007. 25(3): p. 187-95.
产品手册




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